Project Title: Therapeutic Targeting of the Potent Metastasis Suppressor, NDRG1, in Pancreatic Cancer

Dr Zaklina Kovacevic 300x400Dr Kovacevic and Dean Gorddard 300x225

Grant: Innovation Grant 2017
Award: Dean Gorddard Grant

Institution: The University of Sydney

Principal Investigator: Dr Zaklina Kovacevic

Position Held: DVCR Senior Research Fellowship, Senior Lecturer (Research) at the University of Sydney

Time required to complete project: 1 year

Project Summary: The stromal tissue surrounding pancreatic cancer is a major driver of metastasis and therapeutic resistance. This project will examine a novel frontier drug in clinical trials that up-regulates the potent metastasis suppressor, NDRG1, and its role in inhibiting the oncogenic cross-talk between pancreatic cancer cells and the surrounding stroma.

This grant was awarded by Dean Gorddard who, along with the support of his friend Craig Ryman at AMP, have successfully raised over $100k in support of Avner Pancreatic Cancer Foundation. Dean, Craig and the team at AMP have achieved this significant amount by organising various fundraising initiatives including taking part in the 2017 City2Surf run, marathons, fundraising dinners and raffles. Dean was diagnosed with the disease in 2015 and continues to advocate for better survival rates and increased awareness.