Project Title: Development of Novel Agents that Target P-Glycoprotein Resistant Pancreatic Cancer
Grant: Innovation Grant 2016
Institution: University of Sydney
Principal Investigator: Professor Des Richardson
Position Held: Professor of Cancer Cell Biology, NHMRC Senior Principal Research Fellow.
Time required to complete project: 1 year
Project Summary: Drug resistance is a major factor underlying the limited response of pancreatic cancer to chemotherapy. The project team’s drug design strategy is to target resistant pancreatic cancer by taking advantage of detoxifying P-glycoprotein pump to transport our drugs DIRECTLY to their sensitive site of action in the cancer cell (namely, the LYSOSOME).