Project Title: Development of Novel Agents that Target P-Glycoprotein Resistant Pancreatic Cancer

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Grant: Innovation Grant 2016

Institution: University of Sydney

Principal Investigator: Professor Des Richardson

Position Held: Professor of Cancer Cell Biology, NHMRC Senior Principal Research Fellow.

Time required to complete project: 1 year

Project Summary: Drug resistance is a major factor underlying the limited response of pancreatic cancer to chemotherapy. The project team’s drug design strategy is to target resistant pancreatic cancer by taking advantage of detoxifying P-glycoprotein pump to transport our drugs DIRECTLY to their sensitive site of action in the cancer cell (namely, the LYSOSOME).

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